Vitamin D helps cancer patients to live longer!!
The study research done at Michigan State University in East Lansing had shown the data about the people who took vitamin D supplements with those who took have taken placebo for at least 3 years.
The research trail done with about 4 years in follow up and recorded the incidence of cancer and cancer-related deaths in the people who have been involved in the study.
The analysis done in 10 trials with participants number being 79,055 and with an average age of them being 60, and of the 78% being female.
The final analysis showed that vitamin D showed 13% lower risk of dying from cancer compared to the people who used placebo over the period.
Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL, on June 3, 2019.
A recent supplement of the ASCO’s Journal of Clinical Oncology also includes an abstract of the study.
“The difference in the mortality rate between the vitamin D and placebo groups was statistically significant enough that it showed just how important it might be among the cancer population,” says Tarek Haykal, a
resident doctor in internal medicine at MSU and one of the study’s lead authors.
How vitamin D helps cancer patients to live longer?
Cancer develops when cells multiply abnormally and form a tumor that can spread.
Under normal conditions, the cells normally grow old, and later they die, and new cells replace them.
But cancer arises when there is no proper working of the cells leading to process called proliferation where the old cells don’t die and the new cells continue to grow constantly without any control.
These cancer cells grow and spread to the nearby tissue and spread into the blood and the lymphatic system(metastasis) causing the secondaries (cancer in other parts of the body apart from primary).
The chances of survival are more when there is no spread of cancer to distant places in the body.
We get the vitamin D from our skin, where it is synthesized when exposed to the sunlight and from the vitamin supplement, we take.
This vitamin D is converted into an active form in two major organs in two stages: kidneys and liver.
Mechanism of vitamin d function in the body:
The active form of the vitamin D(Calcitrol or 1,25-dihydroxyvitamin D3 ) helps in calcium
absorption from the gut into the blood and keeps your bones strong by helping them get sufficient calcium.
As well as being essential for bone health, vitamin D also helps control cell growth, immune function, and inflammation. It performs these functions by regulating genes for cell differentiation, division, and death.
Calcitriol maintains calcium homeostasis through its actions in the intestine, bone, kidneys, and the parathyroid glands. The hormone exerts its effects through the vitamin D receptor (VDR), a member of the nuclear receptor superfamily.
VDR is present not only in cells and tissues involved in calcium regulation but also a wide variety of other cells including malignant cells.
In recent years it has been recognized that calcitriol exerts anti pro-life rative and differentiating effects in many malignant cells, and retards the development and growth of tumors raising the possibility of its use as an anticancer agent.
It helps in growth arrest and differentiation of the cancer cells and promote the apoptosis( programmed self death of the cells) of the cancer cells and in the spread of the cancer cells to various parts of the body.
Along with the anti-cancer effects it has also the anti-inflammatory effect by inhibiting various cellular level pathways like the regulation of prostaglandin metabolism and signaling Induction of mitogen-activated protein kinase phosphatase-5 (MKP5) and inhibition of stress-activated kinase signaling. Inhibition of NFκB activation and signaling. in this way vitamin D can help cancer patients to live longer
Researches have shown that vitamin D can help cancer patients to live longer by its anti-inflammatory effects and anti-cancer effects.
People who tend to live healthier lifestyles are outside more often and thus are exposed to more vitamin D–generating sunlight. It is better to get tested for vitamin D levels in the blood on a regularly scheduled basis to reduce the risk factors.
Proper supplementation of vitamin D in people who are having insufficiency/ deficiency of the vitamin D can help to maintain proper functioning of the body mechanisms and protects the body from cancer and other various disorders like rickets and osteoporosis.
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