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A New Study Found An Enzyme That Can Reverse Aging!

New research done on mice uncovers a previously unknown "pathway toward healthy aging."

A new study found an enzyme that can reverse aging!

New research  done on mice uncovers a previously unknown “pathway toward healthy aging.”

The researchers have found that a circulating protein from the blood of young mice led to health improvements and visible signs of rejuvenation when researchers gave it to aging mice.

There are  signs like the hair loss, wrinkles, and lessening mobility, less visible, underlying bodily changes also characterize the aging process. These changes are due to the loss of a kind of “fuel” that keeps the body healthy — that is called nicotinamide adenine di-nucleotide (NAD).

This fuel NAD plays important roles in various chemical reactions in our body like the metabolism, DNA repair, and overall aging and longevity. With time, our aging cells find it harder to produce energy, and hence leading to depletion of the NAD. This energy making process needed a special enzyme called as eNAMPT.

This New research found that by taking eNAMPT from the blood of younger mice and giving it to older mice thereby boosting NAD levels and staves off aging.

Dr. Shin-ichiro Imai, Ph.D., who is a professor of developmental biology at Washington University School of Medicine in St. Louis, is the chief research person of this study. His findings appear in the journal Cell Metabolism.

eNAMPT lengthens lifespan by 16%:

In their new research, Dr. Imai and team explain that eNAMPT travels through the bloodstream to the brain in small “carriers” called extracellular vesicles. This fact is true for both mice and humans.

Imai’s research showed that the hypothalamus controls is a major control center for aging, directed greatly by eNAMPT released into the blood from fat tissue. As the levels of eNAMPT decline, the hypothalamus’s ability to function properly also decreases and life span drops.

They also reveal that blood levels of eNAMPT drop with aging, so less of it reaches the brain’s hypothalamus. In turn, the hypothalamus stops working properly, shortening the life span.

In the Cell Metabolism paper, the scientists show that levels of eNAMPT were directly proportional to how long the mice lived.

“That we can take eNAMPT from the blood of young mice and give it to older mice and see that the older mice show marked improvements in health — including increased physical activity and better sleep — is remarkable,” he said.

“Since we know that NAD inevitably declines with age, whether in worms, fruit flies, mice, or people, many researchers are interested in finding antiaging interventions that might maintain NAD levels as we get older,” Imai said in his study.

Researchers said future studies should examine if eNAMPT levels correlate with aging-related diseases or lifespan in humans.

“We could predict, with surprising accuracy, how long mice would live based on their levels of circulating eNAMPT,” Imai  said. “We don’t know yet if this association is present in people, but it does suggest that eNAMPT levels should be studied further to see if it could be used as a potential biomarker of aging.”

Finally, he concluded “We have found a totally new pathway toward healthy aging,”


The new researches done in the field of aging has shown the discovery of the new pathway for the aging. They are discovered a new pathway which involves enzyme protein called eNAMPT which is help in reducing the aging process. The researcher has done their study in mice and has shown the positive results in finding the relationship between the enzyme and delaying the aging process. This discovery had led a spotlight on the studies to delay the aging process in humans.

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