A cup of coffee can fight your obesity!
This is the first study in humans to show that something like a cup of coffee can have a direct effect on our brown fat functions.
The potential implications of our results are pretty big, as obesity is a major health concern for society, and we also have a growing diabetes epidemic, and brown fat could potentially be part of the solution.”
Prof. Michael Symonds
Scientists have confirmed on the human studies that effect of the coffee on the activation of our brown fat – indirectly leading to a decrease in obesity.
There are two types of fat in our body which is brown fat and white fat. Each has a different function of its own.
Brown fat -helps the body turn nutrients into energy and generate heat which can help in healthy weight reduction and said to be good for health.
Initially only attributed to babies and hibernating mammals, it was discovered in recent years that adults can have brown fat too.
The scientists have done various research on the conversion of the white fat to brown fat which could be the healthy way of decreasing the obesity and finally made successful in finding new pathways that would facilitate in this fat browning.
Brown fat metabolizes food into energy by activating the so-called uncoupling protein 1 (UCP1), which exists in the mitochondria of brown adipose tissue.
A team of researchers from the University of Nottingham, United Kingdom, set out to look into this area.
Professor Michael Symonds, from the School of Medicine at the University of Nottingham, is one of the lead authors of the study, which appears in the journal Scientific Reports.
“Brown fat works in a different way to other fat in your body and produces heat by burning sugar and fat, often in response to cold.
Increasing its activity improves blood sugar control as well as improving blood lipid levels and the extra calories burnt help with weight loss. However, until now, no one has found an acceptable way to stimulate its activity in humans.” said Prof. Symonds
Prof. Symonds and team carried out both in vitro and in vivo experiments on stem cell and to see the effect of caffeine on brown fat heat generation, or thermogenesis.
First, they exposed fat-storing cells, or adipocytes — that they derived from stem cells — to caffeine. They noticed that caffeine exposure raised levels of UCP1 and boosted the cells’ metabolism.
The study has shown the browning like the structural changes in the mitochondria and the lipid cells.
Secondly, they have done the thermionic scan tests and found out the heat generation in the body
“From our previous work,” explains Prof. Symonds, “we knew that brown fat is mainly located in the neck region, so we were able to image someone straight after they had a drink to see if the brown fat got hotter.
“The results were positive,” Prof. Symonds reports, “and we now need to ascertain [whether] caffeine, as one of the ingredients in the coffee, is acting as the stimulus or if there’s another component helping with the activation of brown fat. We are currently looking at caffeine supplements to test whether the effect is similar.”
“Once we have confirmed which component is responsible for this, it could potentially be used as part of a weight management regime or as part of [a] glucose regulation program to help prevent diabetes.”
“Increasing [brown fat] activity improves blood sugar control as well as improving blood lipid levels, and the extra calories burnt help with weight loss. However, until now, no one has found an acceptable way to stimulate its activity in humans,” says Prof. Symonds.
The caffeine which is one of the important ingredients in the coffee and tea had shown that to convert the white fat into brown fat – which is called as browning. This browning helps in heat generation in our body and helps in weight reduction.
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