Consuming these bacteria which can decrease your heart-related issues !!
There are various researches that have shown about how to decrease the health risks related to the metabolic health disorders like diabetes and heart disease associated with the obesity, now researches had kept their spotlight on the gut bacteria which can help in decreasing the cardiac-related problems and metabolic conditions associated with it.
They have discovered that having the specific pasteurized form of Akkermansia muciniphila ( gut bacteria)-an intestinal bacteria provides high protection against various heart related risk factors.
According to the findings published in the journal Nature Medicine, the research team from the University of Louvain developed a clinical study regarding this aspect.
Gut microbiota and cardiovascular disease
In the study, 40 participants have enrolled and 32 have completed the trail. The researchers have taken participants who are having the insulin resistant diabetes, obese and other elevated risks for cardiac health problems.
They have administered Akkermansia to these participants following the random division into groups. — placebo group, those taking live bacteria and those taking pasteurized bacteria — and were asked not to change their dietary habits or their physical activity. Akkermansia was provided as a nutritional supplement.
The primary goal of this study was to demonstrate the feasibility of ingesting Akkermansia daily for three months, without risk and they have found excellent compliance – these supplements were having no side effects in the groups taking live or pasteurized bacteria.
As the researchers have already tested the study in the mice model and found good results. The human research which was done later has also shown similar results like decreasing the health risks like cardiovascular diseases, pre-diabetic conditions. Apart from these major health issues, the study has also shown benefit in decreasing the weight of the subjects about 2. 3 kg, lowering the cholesterol content in the blood, and even decreasing the inflammatory markers in the liver.
Clara Depommier, Ph.D., is the lead author of the team’s paper describing the human study, which is published in Nature Medicine, and titled, “Supplementation with Akkermansia Muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.” The authors concluded
Back in 2007, a UCLouvain team headed by senior study author Patrice Cani, Ph.D., an FNRS-WELBIO researcher and working with co-corresponding author Willem de Vos, Ph.D., a professor at the University of Wageningen, demonstrated that A. muciniphila could moderate the development of obesity and type 2 diabetes in mice. Ten years later the team “serendipitously” discovered that giving mice a pasteurized form of Akkermansia, rather than the live bacterium, resulted in even greater protection against key cardiovascular disease risk factors such as insulin resistance, hypercholesterolemia, and adiposity (source)
“Indeed, pasteurized A. muciniphila markedly and significantly improved the insulin sensitivity index by about 30% compared to the placebo group and live A. muciniphila significantly improved the insulin resistance score,” the scientists commented.
The scientists have discovered a new way of fighting metabolic diseases and their related heart issues with the health of the gut bacteria. They have taken the pasteurized gut bacteria named Akkermansia muciniphila and have given it as the supplementation to the human participants after confirming its success in the mice model studies. The research concluded a good impact of the bacteria on the body for fighting the cardiovascular issues and metabolic conditions like diabetes. This research would limit cardiovascular risks and therefore potentially have an impact on half of the population if properly used, researchers said.
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