Baby Born from a Dead Donor’s Transplanted Womb First in U.S. !!
You’re probably familiar with the idea of a kidney, liver or heart transplant, but uterine transplant is a rapidly evolving field.
A healthy baby girl was born from a transplanted uterus given to the mother from a deceased donor, for the first time ever in North America at Cleveland Clinic and the second time worldwide.
While this is the first successful birth in the U.S. involving a uterus from a deceased donor.
A Swedish woman was the first to successfully deliver a healthy baby after a uterus transplant from a living donor back in 2014, and the first in the U.S. occurred in Oct. 2017. In Dec. 2017, a woman in Brazil delivered the first baby born from a uterus transplanted from a deceased donor.
Case report, published in the Lancet, researchers at the University of São Paulo in Brazil removed a uterus from a 45-year-old woman who died from a brain hemorrhage and had three children. The organ was transplanted into a 32-year-old woman who had a disorder that left her without a uterus. Seven months after the transplant, doctors transferred an embryo made via in-vitriol fertilization from the woman’s egg and her husband’s sperm into her womb. (source)
Experts hope uterus transplants will one day be more widely available for women without uterus’s or with damaged organs — or potentially even transgender women — seeking to become pregnant.
Through this research, we aim to make these extraordinary events ordinary for the women who choose this option,” transplant surgeon Andreas Tzakis said in a statement on the hospital’s website.
“We are grateful to the donor. Their generosity allowed our patient’s dream to come true and a new baby to be born.”
Since the uterus can only survive away from a blood supply for so long. Transplants from living donors are scheduled and can take place in adjacent operating rooms.
The researchers in Brazil, the transplant has reported that the uterus was ischemic — meaning, off a blood supply — for almost eight hours, essentially double the reported time from any of the living donor transplants. It suggested that transplant teams looking for uteruses could broaden the geographic area in which they search for donors.
As with other organ recipients, the patient in this case was put on immune suppression drugs to reduce the chances of her body rejecting the transplant. Surgeons also performed a hysterectomy — they removed the uterus — during the C-section. Uterine transplants are considered “ephemeral,” meaning they only stay in to allow the recipient to have children and are then removed.
Researchers in Turkey performed a uterine transplant in 2011 from a deceased donor but have not had any successful pregnancies. Flyckt and her colleagues in Cleveland have also performed two transplants from deceased donors. In the first, the uterus had to be removed from the recipient after an infection occurred; Flyckt said she couldn’t say where things stood with the second case other than that the recipient was doing well.
Part of the challenge in transplanting a uterus from a deceased donor is that the process — obtaining(source)
“It was amazing how perfectly normal this delivery was, considering how extraordinary the occasion,” said Dr. Andreas Tzakis, the Cleveland Clinic’s transplant surgeon
The transplant and birth are part of Cleveland Clinic’s continuing clinical trial on uterine transplantation. They have transplanted five uteruses so far — three have been successful, while the other two later required hysterectomies to remove them because they did not take. Two women who had successful transplants are waiting on their embryo transfer for IVF.
The trial, called Uterine Transplantation for the Treatment of Uterine Factor Infertility is aimed at helping the “estimated 1 in 500 women of childbearing age worldwide” who are unable to get pregnant because of abnormalities in their uteruses.
“Through this research, we aim to make these extraordinary events, ordinary for the women who choose this option,” Tzakis continued.
“We are grateful to the donor and her family, their generosity allowed our patient’s dream to come true and a new baby to be born.”
Researchers not involved in the study cautioned that, given all the biological constraints, the pool of potential uterus donors is actually quite small, even taking into account deceased donors. But they said that relying on deceased donors could expand the options for women who do not have a friend or family member willing to donate or that would be a good match.
Most transplant teams envision one day using uterus’s from both living and deceased donors.
“This is a very important birth for the whole uterus transplant community,” said Dr. Liza Johannes-son, a uterus transplant surgeon at Baylor who previously worked with the Swedish research team. “It’s a landmark birth.” (source)
Medical research is advancing rapidly, you’re probably familiar with the idea of a kidney, liver or heart transplant, but uterine transplant is a rapidly evolving field. Experts hope uterus transplants will one day be more widely available for women without uterus’s or with damaged organs — or potentially even transgender women — seeking to become pregnant. Estimated 1 in 500 women of childbearing age worldwide who are unable to get pregnant because of abnormalities in their uterus. This new medical procedure gave a promising results.
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